THE PERIWINKLE VINCA ROSEASE HERBS HAD VARITY SPECIOUS FOUND THROUGHT INDIA IN ALMOST 45% IN CONTACT WITH HUMAN USED TO WORSHIPED GOD AND HAD VARIOUS MEDICINAL PROPERTIES MENTIONED IN VARIOUS BOOK SINCE 200 BCEIN ANCIENT SABHYATA SADABAR PLANT IS KNOWN AS CELL ON THE WHEEL WHICH ERADICATE THE MALIGNANT DICARCINOMA WITH THE INBUILT ANTI- CANCER CHEMISTRY (POTENT ALKOLOIDS) USED FROM MANY GENERATION AHEAD.VINCA ROSEASE IS ALSO KNOWN AS PROTINE ENGINEERED IN LIVING CELL ORGAN AND BODY WHICH REPAIRED AND TREATMANY DISEASE LIKE DIABETES ANTIVIRAL MALIGNANT CARCINOMA

Vinca rosea (Catharanthus roseus): Ethnobotanical Legacy and Molecular Basis of Anticancer Potential

1. Introduction

Vinca rosea, botanically classified as Catharanthus roseus and commonly known in India as Sadabahar, is a perennial medicinal herb widely distributed across the Indian subcontinent. Ethnobotanical surveys indicate that nearly 40–50% of Indian households maintain this plant, both for ornamental and ritualistic purposes. Since ancient times (≈200 BCE), Vinca rosea has been referenced in traditional medicinal systems, including Ayurveda, Siddha, and folk healing practices, where it was revered not only as a sacred plant but also as a therapeutic agent.

In ancient Indian civilization, Sadabahar was symbolically regarded as a “cell on the wheel”, representing the regulation of life, regeneration, and cellular balance. This metaphor aligns remarkably with modern discoveries of its bioactive compounds that directly influence cell cycle regulation.

2. Cultural and Spiritual Significance

Vinca rosea has historically been used in ritual worship, temple offerings, and domestic spiritual practices. The plant’s evergreen nature symbolized continuity of life, while its ability to thrive under harsh conditions was interpreted as resilience against disease. Such cultural reverence facilitated its preservation and intergenerational transmission of medicinal knowledge.

3. Phytochemical Profile and Alkaloid Chemistry

Modern phytochemical analysis has revealed that Vinca rosea synthesizes over 130 biologically active alkaloids, among which the most significant are:

Vincristine

Vinblastine

Vindesine

Vinorelbine (semi-synthetic derivative)

These compounds are classified as vinca alkaloids, which exhibit potent antimitotic and antineoplastic activity.

4. Mechanism of Action: Cell Cycle Regulation

The anticancer efficacy of vinca alkaloids is primarily attributed to their ability to disrupt microtubule dynamics:

They bind to tubulin, preventing microtubule polymerization.

This leads to cell cycle arrest at the metaphase stage of mitosis.

Prolonged arrest activates intrinsic apoptotic pathways, resulting in selective death of rapidly dividing malignant cells.

Thus, the ancient concept of “cell on the wheel” finds a scientific parallel in mitotic checkpoint control and spindle assembly inhibition.

5. Role in Malignant Disorders

Vinca alkaloids are clinically utilized in the management of several malignancies, including:

Acute lymphoblastic leukemia (ALL)

Hodgkin’s and non-Hodgkin’s lymphoma

Breast carcinoma

Lung carcinoma

Pediatric solid tumors

Importantly, these compounds do not eradicate cancer independently as crude herbal preparations, but rather as purified, standardized pharmaceutical agents developed through rigorous biomedical research.

6. Broader Therapeutic Potential

Traditional medicine systems have described Vinca rosea for conditions such as:

Diabetes mellitus (hypoglycemic effects via insulin sensitivity modulation)

Hypertension

Wound healing

Inflammatory disorders

Modern studies suggest its role in:

Modulating glucose metabolism

Influencing oxidative stress pathways

Regulating immune signaling

However, claims related to AIDS or universal disease cure remain unsubstantiated in evidence-based medicine and should be framed as traditional beliefs or exploratory research hypotheses, not established therapies.

7. Protein and Cellular Engineering Perspective

From a molecular biology standpoint, Vinca rosea may be conceptualized as a natural biochemical factory, capable of synthesizing complex alkaloids through multi-enzyme biosynthetic pathways. These pathways reflect sophisticated plant cellular engineering, involving:

Gene-regulated secondary metabolite synthesis

Enzyme-mediated alkaloid assembly

Stress-responsive metabolic control

This makes Vinca rosea an important model in plant molecular pharmacology and metabolic engineering research.

8. Intergenerational Knowledge and Modern Translation

The continuous use of Sadabahar across generations illustrates the value of traditional knowledge systems as precursors to modern drug discovery. The transition from sacred plant to FDA-approved chemotherapeutic agents represents a successful integration of ancient wisdom with contemporary science.

9. Conclusion

Vinca rosea (Sadabahar) stands as a unique convergence point of spiritual heritage, ethnomedicine, and molecular oncology. While ancient civilizations revered it as a protector against malignant forces within the body, modern science has validated its role through the discovery of potent anticancer alkaloids that directly regulate the cell cycle.

Its significance lies not in mythological absolutism, but in its demonstrated ability to inspire evidence-based therapeutics, reinforcing the importance of conserving medicinal biodiversity and responsibly translating traditional knowledge into modern healthcare.

Suggested Thesis Keywords

Vinca rosea, Catharanthus roseus, vinca alkaloids, vincristine, vinblastine, cell cycle arrest, mitotic checkpoint, ethnobotany, anticancer phytochemistry, traditional medicine.

#VINCA_VACCINE🧬⚛️🛞. IN the cell cycle of different organs there are various checkpoints and stop colons in the gene expression which controls the defected cell to divide in the process of mitosis and myosis with various phases, But what if all the check points dysfunction in various organs can lead to invade malignant carcinoma?

Dysfunction of Cell Cycle Checkpoints and Their Role in Malignant Carcinoma Progression

1. Introduction

The cell cycle is a tightly regulated process that ensures accurate DNA replication, chromosome segregation, and cell division. In multicellular organisms, especially in highly specialized organs, this regulation is essential for maintaining tissue homeostasis. Multiple molecular checkpoints and gene expression controls—such as stop codons, tumor suppressor genes, and signaling cascades—act as surveillance mechanisms to prevent the proliferation of defective cells. When these checkpoints fail across one or more organs, uncontrolled cell division can occur, ultimately leading to invasive malignant carcinoma.

2. Cell Cycle Checkpoints and Genetic Control

The eukaryotic cell cycle consists of four major phases: G1, S, G2, and M, with meiosis occurring in germ-line cells. Critical checkpoints include:

G1/S checkpoint – assesses DNA integrity before replication

Intra-S checkpoint – monitors replication fidelity

G2/M checkpoint – ensures complete and accurate DNA replication

Spindle assembly checkpoint (SAC) – verifies proper chromosome attachment during mitosis

Gene expression is regulated through transcriptional control, mRNA processing, and translational fidelity, including the correct usage of stop codons. Tumor suppressor genes (e.g., TP53, RB1, CDKN2A) and cyclin-dependent kinase (CDK) inhibitors enforce cell-cycle arrest, DNA repair, senescence, or apoptosis when damage is detected.

3. Consequences of Checkpoint Dysfunction

When checkpoint mechanisms become dysfunctional due to mutations, epigenetic alterations, viral oncogenes, or metabolic stress, cells lose the ability to:

Arrest the cell cycle in response to DNA damage

Repair genomic errors effectively

Activate programmed cell death (apoptosis)

Maintain chromosomal stability

This leads to genomic instability, characterized by chromosomal rearrangements, aneuploidy, and accumulation of oncogenic mutations.

4. Mitotic and Meiotic Errors in Malignancy

Checkpoint failure during mitosis results in improper chromosome segregation and uncontrolled proliferation. In somatic cells, this creates clonal populations with growth advantages.

In contrast, aberrant activation of meiosis-related genes in somatic tissues—a phenomenon observed in several cancers—can further destabilize the genome. Such “meiotic gene re-expression” contributes to DNA double-strand breaks and recombination errors, accelerating malignant transformation.

5. Organ-Specific Vulnerability and Systemic Failure

Different organs possess distinct cell-cycle kinetics and regenerative capacities. Tissues with high turnover rates (e.g., epithelium, bone marrow, gastrointestinal tract) are particularly vulnerable to checkpoint failure. When multiple checkpoints fail simultaneously across different organs, the body’s systemic tumor-suppressive network collapses, allowing:

Invasion into surrounding tissues

Angiogenesis and metabolic reprogramming

Immune evasion

Metastatic dissemination

This multiorgan checkpoint failure transforms localized dysplasia into aggressive, invasive carcinoma.

6. From Dysregulation to Invasive Malignant Carcinoma

The progression from normal cell to malignant carcinoma follows a stepwise model:

Checkpoint dysfunction

Accumulation of DNA damage

Loss of growth control and apoptosis resistance

Clonal expansion of transformed cells

Invasion and metastasis

Thus, malignant carcinoma is not caused by a single mutation but by cumulative failure of cell-cycle checkpoints and gene expression controls across time and tissues.

7. Conclusion

In summary, the integrity of cell-cycle checkpoints and precise gene expression—including proper stop codon usage—is fundamental to preventing malignancy. Global dysfunction of these regulatory systems across different organs permits defective cells to bypass mitotic and meiotic control, leading to genomic instability, uncontrolled proliferation, and invasive malignant carcinoma. Understanding these mechanisms provides a critical foundation for targeted cancer therapies and checkpoint-based interventions.

#HARGHARVINCA🧬⚛️🛞

#HARGHARMADHUVINCA🧬⚛️🛞

#KOSHIKA_POOJAN🧬⚛️🛞

#CHECKPOINT_CARCINOMA🧬⚛️🛞

#STOP_CODON🧬⚛️🛞

#GENELOCKING🧬⚛️🛞

 #CELL_ON_THE _WHEEL🧬 ⚛️🛞

THE CELL ON THE WHEEL 🛞

Introduction 

THE UNPAIRED GENE EITHER DNA mRNA NUCLEOUS NUCLEOTIDE RIBOSOME MITOCONDRIAL PATHWAYS AND VARIOUS GLYCOLYSIS PATHWAY LIKE KREB CYCLE PYARUVATE ADINOSINE PHOSPHATE TYOSINE ADENINE TRY PHOSPHATE WITH INTRUSIVE GENE EXPRESSION AND MUTANT SOME TIME INHERITANCE UPPER MANY GENERATIONS OF FAILURE  INFILTERED CAUSE FOR DIFFERENCIAL CARCINOMA ⚛️

Modern molecular-biology understanding.

1. What is meant by an “unpaired gene” ⚛️

An unpaired gene usually refers to:

Loss of normal allelic balance (one functional copy + one damaged copy)

Or abnormal gene dosage (extra copies, deletions, or silencing)

This can happen due to:

Mutations

Chromosomal instability

Epigenetic silencing

Mitochondrial DNA defects

When genes are no longer properly paired or regulated, cellular homeostasis collapses.

2. DNA → mRNA → Ribosome: where failure begins 🧬

Normal flow (Central Dogma):

DNA (nucleus) → mRNA → Ribosome → Protein

In carcinoma:

DNA mutations (point mutation, deletion, insertion)

Faulty transcription → abnormal mRNA

Faulty translation → abnormal proteins

Key problems:

Oncogene activation (e.g., uncontrolled growth signals)

Tumor suppressor gene loss (e.g., p53, RB)

Stop codon failure or frame-shift errors

Ribosome produces misfolded or hyperactive proteins

Result → uncontrolled cell division

3. Intrusive gene expression & mutant inheritance 🧪

Intrusive gene expression means:

Genes that should be OFF become ON

Embryonic, viral, or silent genes get reactivated

External DNA (virus, transposons) integrates into genome

Inheritance across generations:

Germline mutations (BRCA, TP53, mismatch repair genes)

Epigenetic inheritance (DNA methylation patterns)

Mitochondrial DNA mutations passed from mother

This explains:

Cancer predisposition running in families

“Upper many generations of failure” as you mention

4. Mitochondrial pathway failure 🔥

Mitochondria control:

ATP production

Apoptosis (programmed cell death)

Reactive oxygen species (ROS balance)

In carcinoma:

Mitochondrial DNA mutations

Faulty electron transport chain

Excess ROS → DNA damage

Failure of apoptosis → cancer cells survive

Cancer cells avoid death even when damaged.

5. Glycolysis, Krebs cycle & Warburg effect ⚙️

Normal cells:

Glucose → Pyruvate → Krebs Cycle → ATP (mitochondria)

Cancer cells:

Prefer glycolysis even with oxygen

(Warburg Effect)

This causes:

Excess lactate production

Acidic microenvironment

Rapid biomass synthesis (DNA, lipids, proteins)

Pathways involved:

Glycolysis ↑

Pyruvate diverted away from Krebs cycle

ATP generated inefficiently but rapidly

Supports uncontrolled proliferation

6. ATP, ADP, AMP imbalance ⚡

You mentioned:

Adenosine phosphate system

In cancer:

ATP demand is extremely high

AMPK signaling is altered

Energy checkpoints fail

Cells divide even under stress

This removes normal metabolic brakes.

7. Tyrosine, adenine & signaling failure 🧠

Tyrosine kinase pathways:

EGFR, HER2, BCR-ABL

When mutated → constant “growth ON” signal

Adenine base errors:

DNA replication mismatch

Defective repair enzymes

Accumulation of mutations

Result → genomic instability

8. Why this leads to differential carcinoma 🌱

Different tissues show different carcinoma because:

Each tissue has unique gene expression

Different metabolic dependence

Different mitochondrial density

Different exposure to carcinogens

Thus:

Lung carcinoma ≠ liver carcinoma ≠ breast carcinoma

Same basic failure, different manifestation

9. Unified summary ⚛️

Differential carcinoma arises from:

Unpaired or damaged genes

Abnormal DNA → mRNA → protein flow

Intrusive or inherited mutant gene expression

Mitochondrial dysfunction

Shifted metabolism (Warburg effect)

ATP signaling imbalance

Failure of apoptosis

Accumulation across generations

This creates a self-sustaining malignant system.

#HARGHARVINCA🧬

#HARGHARMADHUVINCA🧬

#TSAC⚛️

#AILIfe⚛️

KOSHIKA POOJAN -THE CELL ON THE WHEEL 🛞

1. “अनपेयर्ड जीन” (Unpaired Gene) क्या है ⚛️

सामान्य स्थिति में प्रत्येक जीन जोड़ी (pair) में होता है।

जब यह संतुलन बिगड़ जाता है, तो उसे अनपेयर्ड या असंतुलित जीन कहा जा सकता है।

यह कारणों से होता है:

जीन में म्यूटेशन (Mutation)

जीन की कॉपी कम या अधिक हो जाना

जीन का साइलेंट हो जाना (Epigenetic silencing)

माइटोकॉन्ड्रियल DNA की खराबी

इससे कोशिका का प्राकृतिक संतुलन टूट जाता है।

2. DNA → mRNA → राइबोसोम में गड़बड़ी 🧬

सामान्य प्रक्रिया (Central Dogma):

DNA (न्यूक्लियस) → mRNA → राइबोसोम → प्रोटीन

कैंसर में क्या होता है:

DNA में गलती आ जाती है

mRNA गलत संदेश बनाता है

राइबोसोम गलत या विकृत प्रोटीन बनाता है

मुख्य समस्याएँ:

ऑन्कोजीन सक्रिय हो जाते हैं (अनियंत्रित वृद्धि)

ट्यूमर सप्रेसर जीन बंद हो जाते हैं

स्टॉप कोडॉन की विफलता

फ्रेम-शिफ्ट एरर

परिणाम → कोशिकाएँ बिना रुके विभाजित होने लगती हैं।

3. इंट्रूसिव जीन एक्सप्रेशन और वंशानुगत दोष 🧫

इंट्रूसिव जीन एक्सप्रेशन का अर्थ:

जो जीन बंद होने चाहिए, वे चालू हो जाते हैं

भ्रूणीय या वायरल जीन सक्रिय हो जाते हैं

बाहरी DNA (वायरस, ट्रांसपोसॉन) जीनोम में जुड़ जाता है

पीढ़ियों तक प्रभाव:

जर्मलाइन म्यूटेशन (जैसे BRCA)

एपिजेनेटिक परिवर्तन

माइटोकॉन्ड्रियल DNA माँ से संतान में

इसलिए कुछ कैंसर परिवारों में पीढ़ियों तक चलते हैं।

4. माइटोकॉन्ड्रियल मार्ग की विफलता 🔥

माइटोकॉन्ड्रिया:

ऊर्जा (ATP) बनाता है

कोशिका मृत्यु (Apoptosis) नियंत्रित करता है

फ्री रेडिकल संतुलन रखता है

कैंसर में:

माइटोकॉन्ड्रियल DNA खराब

ऊर्जा उत्पादन विकृत

ROS बढ़ता है → DNA को नुकसान

Apoptosis रुक जाती है

कैंसर कोशिकाएँ मरती नहीं हैं।

5. ग्लाइकोलाइसिस, क्रेब्स चक्र और वारबर्ग प्रभाव ⚙️

सामान्य कोशिका:

ग्लूकोज → पाइरुवेट → क्रेब्स चक्र → ATP

कैंसर कोशिका:

ऑक्सीजन होते हुए भी ग्लाइकोलाइसिस पर निर्भर

इसे वारबर्ग प्रभाव कहते हैं

परिणाम:

लैक्टिक एसिड बढ़ता है

कोशिका के आसपास अम्लीय वातावरण

तेज़ कोशिका वृद्धि

6. ATP, ADP, AMP संतुलन का टूटना ⚡

कैंसर में:

ATP की मांग बहुत अधिक

ऊर्जा चेकपॉइंट फेल

कोशिका तनाव में भी विभाजित होती रहती है

यह प्राकृतिक ब्रेक सिस्टम को तोड़ देता है।

7. टायरोसिन, एडेनिन और सिग्नलिंग गड़बड़ी 🧠

टायरोसिन किनेज मार्ग:

EGFR, HER2 जैसे रिसेप्टर

म्यूटेशन से हमेशा “ON” रहते हैं

एडेनिन बेस की त्रुटि:

DNA कॉपी करते समय गलती

रिपेयर सिस्टम फेल

परिणाम → जीनोमिक अस्थिरता

8. डिफरेंशियल कार्सिनोमा क्यों होता है 🌱

हर अंग में:

अलग जीन सक्रिय होते हैं

अलग ऊर्जा जरूरत

अलग माइटोकॉन्ड्रिया संख्या

इसलिए:

फेफड़ा कैंसर अलग

लिवर कैंसर अलग

स्तन कैंसर अलग

मूल कारण समान, रूप अलग।

9. संक्षेप में ⚛️

डिफरेंशियल कार्सिनोमा का कारण है:

जीन असंतुलन

DNA–mRNA–प्रोटीन प्रणाली की विफलता

वंशानुगत एवं इंट्रूसिव म्यूटेशन

माइटोकॉन्ड्रियल खराबी

बदला हुआ ऊर्जा चक्र

Apoptosis का रुकना

यह मिलकर कैंसर को जन्म देता है।

NERVE CELL INATROPHY AND MILD TO MODERATE PARALYTIC BRAIN HEMORRHAGE POST OPERATIVE TREATMENT PROTOCOL WITH BRAIN-TONICS ⚛️🏌🏻

#Hargharvinca🌱 #LIfeAI🧬 # VEDA_CULTURE #HARGHARMADHUVINCA⚛️

Plant CATHRENTHOUS ROSEASE IN YOUR HOME OR WORK PLACE TAKE A SELFIE AND SHARE TO SOCIAL MEDIA 

START WITH MEDITATION & yoga  ATLEAST 30MIN. EVERYDAY WITH FLOWER WORSHIP TO THE GOD

[Mild nerves paralysis or Brain Haemorrhage]🎋🌾☘️

NEUROBION FORTE OD 30DAYS

Sankha Pusphi syrup- 10ml BD for 60 days

Ashwagandha powder - 2 tablespoon in milk before sleeping at night for 60days

Physiotherapist excercise for 2 Month 

Than continue with yourself for 6 month until it  heals upto 80-90%

Stricly AVOID NICOTINE & ALCOHOL 

DONT STOP TAKING YOUR REGULAR, MAIN STREAM METHOD ( ALOEPATHIC MEDICATIONS PRISCRIBED YOUR PHYSICIAN) 

#VEDA_CULTURE_200_BCE

#HarGharVinca⚛️🤘🏻

#TSAC⚛️🤘🏻

#LIfeAI⚛️🤘🏻

#MARS⚛️🔥

#BRAINTONIC_ASHWAGANDHA🛞⚛️

#BRAINTONIC_SANKHAPUSPHI🛞⚛️

#HARGHARVINCA - THE LIVING CELL DUPLICATION SOLUTION AND STOP CODON GENE PROTOCOL VEDANTA

#HARGHARVINCA🎋⚛️🤟

#AYURVEDACULTURE🌱🤘🏻⚛️

हर घर विनका एक मुहिम है जिसका अर्थ है जानलेवा बिमारिया को जद से ख़तम किया जय जो कि अब तक उसका इलाज संभव नहीं है !

जैसे 88 प्रकार के कैंसर, मधुमेह एड्स आदि 

हर घर विनाका का अर्थ है सदाबहार पेरिविंकल विंका पौधे का अपने घर, बालकनी, फैक्ट्री, दुकान, और बगीचे में मुख्य लगाएं और इसकी पूजा करें और पुष्प को भगवान जी को अर्पण करें ये एक आयुर्वेदहर घर विनका एक मुहिम है जिसका अर्थ है जानलेवा बिमारिया को जद से ख़तम किया जय जो कि अब तक उसका इलाज संभव नहीं है !

जैसे 88 प्रकार के कैंसर, मधुमेह एड्स आदि 

हर घर विनाका का अर्थ है सदाबहार पेरिविंकल विंका पौधे का अपने घर, बालकनी, फैक्ट्री, दुकान, और बगीचे में मुख्य लगाएं और इसकी पूजा करें और पुष्प को भगवान जी को अर्पण करें ये एक आयुर्वेद संस्कृति है  मैं पौधे के आश्रय से आपके घर से इन बिमारियो का नाश होगा ! ये पौधे को लगाने का अर्थ ये नहीं है कि सारी दवाई एवं उपचार बंद करनी है ये एकपूजा एवं ध्यान है जिसका असर जल्दी मिलेगा | #हरघरविंका से जुड़ें और कैंसर के दर्द और संक्रमण से मुक्ति पायें! 

##हरघरविंका

HAR GHAR VINCA- THE SMILE AND CHARM (TSAC) MISSIONS TO ERADICATE LIFE THREATENING DISEASES WITHIN TWO YEARS AROUND THE WORLD

HAR GHAR VINCA- THE SMILE AND CHARM (TSAC) MISSIONS TO ERADICATE LIFE THREATENING DISEASES WITHIN TWO YEARS AROUND THE WORLD

HAR GHAR VINCA IT IS THE MISSION TO GIVE SMILE AND CHARM TO THE VICTIMS OF LIFE THREATENING DISEASES WHO ACTUALLY DESERVED IT.

I CAN FEEL THE PAIN THOSE WHO ARE UNDER TREATMENT AND OFF THE TREATMENT

THE UNBAREBLE PAIN BEFORE THEY FELT IN THERE BEFORE AND LAST STAGES

CATHRENTES ROSES, MADAGASCAR PERIWINKLE, VINCA ROSASEA

The term "periwinkle roses" most likely refers to the Madagascar Periwinkle plant (Catharanthus roseus), which has flower color varieties including shades of pink ("rosy" periwinkle), red, white, and purple, but typically not a true blue or "periwinkle blue" color. It is a popular, low-maintenance ornamental plant.

General Plant Review

The Madagascar Periwinkle is highly valued by gardeners for several reasons:

Ease of Growth & Hardiness: It is an exceptionally resilient and low-maintenance plant, suitable for both novice and experienced gardeners. It is known for its ability to thrive in poor or sandy soil and hot, dry conditions, making it a great option for heat-prone areas.

Aesthetic Value: It features glossy, dark green leaves and produces an abundance of showy, five-petaled, star-shaped flowers that bloom continuously throughout the warm season or year-round in tropical climates.

Versatile Use: It is commonly used in garden beds, borders, containers, hanging baskets, and as a ground cover to suppress weeds and control erosion.

Attracts Pollinators: The flowers attract bees, butterflies, and other pollinators to the garden.

Disease Resistance: Modern cultivars, such as those in the 'Cora' series, have been bred to be resistant to common fungal diseases like aerial blight, which can be an issue in overly wet conditions.

Important Considerations

Toxicity: All parts of the Catharanthus roseus plant are toxic if ingested. It should be handled with care and kept out of reach of children and pets. Do not attempt to use it for home remedies, as the medicinal compounds used in chemotherapy drugs like vincristine and vinblastine are isolated and administered under strict medical supervision.

Watering: A common mistake is overwatering. The plant prefers well-drained soil and is quite drought-tolerant once established. It is sensitive to wet roots, which can lead to root rot.

Sunlight: While it can tolerate partial shade, it performs best and produces the most flowers in full sun (at least six hours of direct sunlight daily).

Invasive Potential: In very warm, frost-free regions (USDA zones 10-11), it can self-seed prolifically and may become an invasive species or garden escape, so planting location should be considered carefully in those areas.

Overall, the Madagascar Periwinkle is a beautiful and rewarding plant for adding reliable color to a sunny, dry garden or container, provided its toxicity and water drainage needs are respected.

CONCLUSION

IN INDIA IT IS CULTURE YOU ALSO FOLLOW THIS CULTURE FOR HUMINITY AND MANKIND WITH MY 'SOCH'

PLANT ATLEAST ON PLANT IN YOUR HOME OFFICE SHOPS GARDEN BOLCANY EVERY WERE IF YOU LOVE THE VICTIM YOU KNOW FOR YOUR FAMILY, RELATIVES, FRIENDS FOR MANKIND

PLANT THE CATHRA THUS ROSES TAKE A SELFIE AND SHARE TO YOUR SOCIL NETWORK MANUALLY OR DIGITALLY

TAG- #HARGHARVINCA #TSAC

'THE SMILE AND CHARM'

IT WILL MAKE THE DIFFERENCE BY JOIN MY HAND

#HARGHARVINCA

#HARGHARMADHUVINCA

#TSAC