EVALUATION OF ANTI-INFLAMMATORY ACTION OF AQUAOUS AND ETANOLIC EXTRACT OF THE LEAVES OF CALOTROPIS GIGANTEA IN CARRAGEENAN INDUCED RAT PAW EDEMA IN ALBINO RATS

 Carrageenan-induced rat paw edema model

The rats were divided into eight groups (n = 6), each receiving distilled water (control), diclofenac 20 mg/kg p.o. (reference standard), and 50, 100, 200 mg/kg p.o. dose of the AE and EE of C. Gigantea  respectively. Carrageenan (0.1 mL of 1%) was injected into the subplantar tissue of the right hind-paw of each rat. The volume of the carrageenan injected into the foot was measured at 0, 30, 60, 120, and 180 minutes using a plethysmometer (Biodevices, New Delhi, India). The percentage inhibition (PI) at each time interval was calculated$\text{PI}=\frac{{(\text{V}}_{\text{t}}-{\text{V}}_{\text{0}})\text{control}-({\text{V}}_{\text{t}}-{\text{V}}_{\text{0}})\text{treated}}{({\text{V}}_{\text{t}}-{\text{V}}_{\text{0}})\text{control}}\times \mathrm{100PI}$

PI= (Vt-V0) Control - (Vt-V0)Teatment*100

Upon

(Vt-V0) Control

V0 = Mean paw volume at 0 hours

Vt = Mean paw volume at a particular time interval

Ref :Vogel

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